Fenerbahce broke open a tight game in the third quarter at Nadezhda and won for the 11th consecutive time in the EuroLeague Women on Wednesday.
The Turkish giants trailed 42-34 early in the second half but took command with a 10-3 run and ended up winning, 72-60.
Angel McCoughtry led the winners with 24 points, while a pair of Latvia internationals made important contributions in a key stretch of the game that put Fener in front to stay.
A three-point play by Zane Tamane gave the visitors a 48-46 advantage and two Elina Babkina free-throws followed to make it a four-point lead.
McCoughtry then added two more from the stripe to increase her points haul to 20 and Fenerbahce had their noses in front to stay.
Going to the fourth quarter behind 58-50, Nadezhda drew to within five when Elena Berseneva drilled a three-ball, but they got no closer.
McCoughtry, Birsel Vardarli and Tamane each made jumpers in a 6-0 run as Fener moved back in front by double digits and coasted to another impressive victory under coach George Dikeoulakos.
Tamane finished with 10 points and eight rebounds and Penny Taylor added 10 points with six boards.
Fenerbahce's defense held Nadezhda to just 25 of 64 shooting from the floor.
Nadezhda, who came into this week's game in third place in Group B, dropped to 6-5 with the defeat.
They were led by Rebekkah Brunson's 14 points and eight rebounds, while Anastasiya Verameyenka had 11 boards to go with her eight points.